- Title
- Genome-wide association study identifies five new schizophrenia loci
- Creator
- The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium; Henskens, Frans A.; Loughland, Carmel M.; Michie, Patricia T.; Schall, Ulrich; Scott, Rodney J.
- Relation
- Nature Genetics Vol. 43, Issue 10, p. 969-976
- Publisher Link
- http://dx.doi.org/10.1038/ng.940
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2011
- Description
- We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10−11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10−9), ANK3 (rs10994359, P = 2.5 × 10−8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10−9).
- Subject
- schizophrenia; genome wide association study; microRNA 137; bipolar disorder
- Identifier
- http://hdl.handle.net/1959.13/1043976
- Identifier
- uon:14264
- Identifier
- ISSN:1061-4036
- Language
- eng
- Full Text
- Reviewed
- Hits: 10552
- Visitors: 3971
- Downloads: 374
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 1 MB | Adobe Acrobat PDF | View Details Download |